Hot melt extrusion (HME) is a versatile and widely used technology in the pharmaceutical industry for the development of amorphous solid dispersions (ASDs), controlled release systems, and other specialized drug formulations. The process involves melting and mixing active pharmaceutical ingredients (APIs) with polymers and other excipients to create a uniform product with enhanced solubility and stability. The choice of polymer is crucial in HME, as it directly affects the physical stability, solubility, and release characteristics of the final product.

Hot melt extrusion (HME) has emerged as a pivotal technology in the pharmaceutical industry, offering a solvent-free, continuous process for producing various drug delivery systems. This technology has gained significant attention due to its ability to enhance the solubility and bioavailability of poorly soluble drugs, develop abuse-deterrent formulations, and create customized drug delivery systems. In this article, we will explore the latest innovations in hot melt extrusion technology, including advancements in equipment, applications, and process analytical technologies.