Hot melt extrusion (HME) is a versatile and widely used technology in the pharmaceutical industry for the development of amorphous solid dispersions (ASDs), controlled release systems, and other specialized drug formulations. The process involves melting and mixing active pharmaceutical ingredients (APIs) with polymers and other excipients to create a uniform product with enhanced solubility and stability. The choice of polymer is crucial in HME, as it directly affects the physical stability, solubility, and release characteristics of the final product.